Investigators from the University of Utah and the University of Southern California evaluated whether measuring epigenetic changes in sperm DNA could be used to predict male infertility. Philip Uren, Ph. The standard test to determine male infertility, a semen analysis, looks at sperm count, shape or motility. Such DNA marks can change with age, lifestyle, environmental exposure and are known to be heritable. Episona is currently commercializing this technology, and hopes to have a diagnostic test on the market in The study examined whether the DNA methylation profile of a semen sample could predict its fertility status, or the likelihood of the sample giving rise to good-quality embryos during IVF.
Recent advances in understanding & managing male infertility
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In his case, his sperm count — the main marker of male fertility — was not even deemed problematic. But he avoided alcohol, stopped smoking dope, wore loose underpants, and followed the approved advice to maximise sperm production, all to no avail — no specific issue was diagnosed and yet his wife did not get pregnant. He felt as if he was falling short of what was required of him as a man. And that failure made him paranoid, frustrated, envious and angry.
Male and female infertility testing
Order now. Knowing the exact cause of infertility allows for better diagnostic decisions, and enables enhanced counseling for parents with regard to risks for their children. For this reason, genetic testing has the potential to help a significant number of couples in their wish to have children. Infertility is a complex disease of the reproductive system characterized by the inability to achieve pregnancy after more than 12 months of regular, unprotected sexual intercourse. Infertility can be hormonal, related to age, exercise, obesity or infectious disease; it can be immunological, psychological, result from surgery or blockage, or be associated with defined abnormalities in the gametes.
Along those lines, research groups are continuing to explore current social and environmental factors, including the obesity epidemic, and their effects on male fertility potential. Despite these advancements, however, medical treatment options have seen little progress. Concerted collaborative efforts will be needed as we move forward to better understand the challenges men face when struggling to conceive. Several studies have demonstrated an ominous decline in overall sperm quantity and quality in the last several decades, with some blaming the obesity epidemic as the cause 2 , 3. Large multi-institutional studies are being designed to analyze body habitus and other current social and environmental factors and their relationship with male fecundity.